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Lay Summary

Surgery is a common treatment for cancer of the colorectal system. A group of side effects that can occur after having this surgery is called Low Anterior Resection Syndrome (LARS). These side effects can include faecal incontinence, incomplete emptying and an increase in urgency. Changes in bowel function can significantly impact patients and their quality of life.

The POLARIS-pilot study aims to establish the prevalence of LARS in patients who have had colorectal surgery and investigate the treatment options available. These treatment options include optimised conservative management, transanal irrigation and sacral neuromodulation.

Study Details

  • Full title of clinical trial: Feasibility cohort study with an embedded randomised control trial to assess treatment options for patient with major low anterior resection syndrome to establish a Pathway Of Low Anterior Resection syndrome relief after Surgery (POLARiS)
  • Study design: A randomised, control, open-label, multicentre trial with 3 parallel treatment arms.
  • Chief Investigator: Mrs Julie Cornish, Colorectal Surgeon
  • Sponsor: Cardiff and Vale University Health Board
  • Funding: Bowel Research UK