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Clinical research

CEDAR carries out clinical trial management functions including:

  • Facilitating new studies - methodology, systematic reviews, PPI, costing, grant applications, protocol development
  • Regulatory/governance considerations – Sponsorship, REC, MHRA, local approvals
  • Trial management – randomisation, essential trial documentation, site monitoring, committees,
  • Data management – CRF design, questionnaires, database design and testing, SOPs, data review and entry.
  • Safety – adverse event review and reporting.
  • Statistics and reporting – sample size, SAP, statistical analysis and review, study reports, publications. 

CEDAR is staffed by a highly experienced and multi-disciplinary team of both NHS and Cardiff University employees. Senior trial managers/researchers take responsibility for all aspects of our portfolio of trials, with named individuals actively leading the study design, regulatory approvals processes, conduct/monitoring, analysis, and reporting.

CEDAR’s robust quality assurance system ensures that we meet appropriate regulations and legislation, including the principles of Good Clinical Practice (GCP), the NHS Research Governance Framework, the Data Protection Act and the UK Regulations that implement the EU Directive for Clinical Trials.

We work with clinicians, academic researchers, commercial/industry partners, and third sector organisations.

CEDAR's research studies


Feasibility of developing personalised treatment pathways for relief of plantar heel pain using a sequential multiple assignment randomised trial (SMART) study design


Patient-Reported Experience Measures in Vascular Surgery Enhancement Study (PREMIERE) is a sequential mixed-methods study using focus groups and interviews to develop and validate a vascular PREM tool.


A single centre, open-label, feasibility randomised controlled trial to evaluate home-based personalised virtual reality physiotherapy rehabilitation compared to standard physiotherapy exercises for people with knee osteoarthritis pain.


This is a single site Clinical Investigation testing an existing cardiac pacemaker in a new patient group. The aim is to see if pacing will help improve the mechanics of the heart when patients are exercising.


POLARiS is a prospective, international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort study (TWiCs design), with internal pilot phase, qualitative sub-study and economic evaluation.


A qualitative study using focus groups to explore patient views on the visualisation of patient-level patient-reported outcome measures (PROMs) in three exemplar clinical areas


A single centre, open-label, feasibility randomised controlled trial to evaluate gastric microaspiration in critically ill patients intubated using the Venner PneuX system compared to standard of care using pepsin biomarker (VAP-X)


Feasibility cohort study with an embedded randomised control trial to assess treatment options for patient with major low anterior resection syndrome to establish a Pathway Of Low Anterior Resection syndrome relief after Surgery (POLARiS)


A mixed methods evaluation of a technical garment to aid mobilisation of patients with tracheostomies who are dependent on ventilators.

Humigard evaluation study (HEAT)

Quality of Recovery and Perioperative Hypothermia in Elective Colectomy Patients: A Feasibility Study of a Blinded Randomised Controlled Trial

Hughes abdominal repair trial (HART)

Hughes Abdominal Repair Trial - abdominal wall closure techniques to reduce incidence of incisional hernias: a multi-centre pragmatic randomised trial


Process evaluation of the ADAPT-Sepsis trial using mixed methods to investigate factors influencing implementation of biomarker-guided antibiotic prescribing in suspected sepsis.

Argus II CTE

This study is for a mixed methods, multicentre, controlled (before vs after design), prospective, interventional study on ten participants to evaluate the impact of the Argus II epiretinal prosthesis on participants’ quality of life.

Cardiff Cardiac Ablation PROM (C-CAP)

A multicentre, prospective observational study to develop, evaluate and validate Patient Reported Outcome Measures (PROMs) for patients treated with cardiac ablation for symptomatic cardiac arrhythmias

ReCell RCT

A feasibility RCT, comparing ReCell plus meshed skin grafts to meshed skin grafts alone, in patients with severe burns.


Pragmatic randomised controlled trial of MIST ultrasound therapy compared to UK standard care for the treatment of non-healing venous leg ulcers.

Parafricta RCT

The Parafricta RCT aimed to investigate whether Parafricta bootees reduced the incidence of heel pressure ulcers in immobilised hospital patients when compared to standard care.