REDUSE

Background 

Septic shock is a life-threatening condition that happens when a person’s blood pressure drops to a dangerously low level after an infection. When someone is admitted to intensive care unit (ICU) with septic shock it is common to give them large amounts of fluid. Some of the fluid is given to stop dehydration, while some may be given, for example, together with medications or as nutrition. Fluid administration can be life-saving, but research suggests that too much fluid can be harmful. 

We are carrying out a study on adult in ICU with septic shock to see if reducing how much fluid they are given can improve the course of their condition, and ultimately improve their chances of survival. The study is a randomised controlled trial which will take place in ICU departments in the UK, Sweden and elsewhere. Eligible patients will be allocated to a treatment group, either “usual” fluid amount and reduced fluid amount. The team caring for the patient will know which group the participant has been allocated to, but the participant, their family, and other staff involved in the trial will not.

We will measure whether participants are alive, and if so, their health, function, and quality of life. We will collect data during participants’ time in the ICU, and at 3, 6, and 12 months after entering the study.

The results of the study will be used to help doctors and nurses to make the best decisions in the care of patients with septic shock.

CEDAR’s role

• Development of UK-specific study documentation
• Submission to HRA/HCRW and REC for UK-wide approvals
• Submission of amendments 
• Trial management support to UK Lead Site (Cardiff)
• Monitoring UK sites