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Clinical trials

Cedar carries out clinical trial management functions including:

  • Facilitating new studies - methodology, systematic reviews, PPI, costing, grant applications, protocol development
  • Regulatory/governance considerations – Sponsorship, REC, MHRA, local approvals
  • Trial management – randomisation, essential trial documentation, site monitoring, committees,
  • Data management – CRF design, questionnaires, database design and testing, SOPs, data review and entry.
  • Safety – adverse event review and reporting.
  • Statistics and reporting – sample size, SAP, statistical analysis and review, study reports, publications. 

Cedar is staffed by a highly experienced and multi-disciplinary team of both NHS and Cardiff University employees. Senior trial managers/researchers take responsibility for all aspects of our portfolio of trials, with named individuals actively leading the study design, regulatory approvals processes, conduct/monitoring, analysis, and reporting.

Cedar’s robust quality assurance system ensures that we meet appropriate regulations and legislation, including the principles of Good Clinical Practice (GCP), the NHS Research Governance Framework, the Data Protection Act and the UK Regulations that implement the EU Directive for Clinical Trials.

We work with clinicians, academic researchers, commercial/industry partners, and third sector organisations.

Cedar's clinical trials

Humigard evaluation study (HEAT)

Quality of Recovery and Perioperative Hypothermia in Elective Colectomy Patients: A Feasibility Study of a Blinded Randomised Controlled Trial

Hughes abdominal repair trial (HART)

Hughes Abdominal Repair Trial - abdominal wall closure techniques to reduce incidence of incisional hernias: a multi-centre pragmatic randomised trial

PREADAPT

Process evaluation of the ADAPT-Sepsis trial using mixed methods to investigate factors influencing implementation of biomarker-guided antibiotic prescribing in suspected sepsis.

UK-ROPE

ROPE registry project to determine the safety and efficacy of prostate artery embolisation (PAE) for lower urinary tract symptoms secondary to benign prostatic enlargement (LUTS BPE).

SIRT-CTE

This prospective, single-arm, observational, service evaluation study on Selective internal radiotherapy (SIRT) in patients with advanced liver metastases in 10 NHS hospitals in England. This was part of NHS England's Commissioning through Evaluation (CTE) programme. 

Cardiff Cardiac Ablation PROM (C-CAP)

A multicentre, prospective observational study to develop, evaluate and validate Patient Reported Outcome Measures (PROMs) for patients treated with cardiac ablation for symptomatic cardiac arrhythmias

MIST

Pragmatic randomised controlled trial of MIST ultrasound therapy compared to UK standard care for the treatment of non-healing venous leg ulcers.